Ledipasvir: What It Is and Why It Matters

Ledipasvir is an antiviral pill that fights hepatitis C virus (HCV). It’s usually taken together with another drug called sofosbuvir, and together they form a combo known as Harvoni. This combo targets the virus at two different stages, making it harder for HCV to keep replicating.

People use ledipasvir when they have chronic hepatitis C genotype 1, 4, 5, or 6. It’s popular because the treatment course is short—often just 8 to 12 weeks—and many patients clear the virus completely, meaning the virus becomes undetectable in blood tests.

How to Take Ledipasvir Correctly

Take the tablet once a day, with or without food. Swallow it whole; don’t crush or split it. If you’re on the fixed‑dose combo with sofosbuvir, that single pill covers both drugs, so there’s no need to manage two separate schedules.

Stick to the prescribed length. Stopping early can let the virus bounce back, and skipping doses reduces the chance of cure. If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose—then just continue as usual. Never double up.

Typical Dosage and Adjustments

The standard dose for adults is one 90 mg ledipasvir tablet (combined with 400 mg sofosbuvir) daily. Some patients with severe kidney problems may need a doctor’s close monitoring, but the dose itself doesn’t change.

Pregnant or breastfeeding women should discuss risks with their doctor. While ledipasvir isn’t known to cause major birth defects, the safety data are limited, so a professional’s guidance is essential.

Common Side Effects You Might Feel

Most people tolerate ledipasvir well. The most frequent complaints are mild and include fatigue, headache, and occasional nausea. A few patients notice a rash or mild diarrhea; these usually disappear on their own.

If you get a severe rash, trouble breathing, or swelling of the face or tongue, seek medical help right away—these could be signs of an allergic reaction.

Things to Watch Out For

Ledipasvir can interact with several medicines. Antacids that contain aluminum, magnesium, or calcium, as well as certain heartburn drugs (like omeprazole), can lower how much ledipasvir gets into your bloodstream. If you need those medicines, take them at least four hours before or after the antiviral.

Other drugs that may clash include amiodarone (a heart rhythm medication) and certain HIV or hepatitis B treatments. Always give your pharmacist a full list of what you’re taking.

When to Call Your Doctor

If you notice persistent jaundice (yellow skin or eyes), dark urine, or a sudden increase in fatigue, contact your healthcare provider. These could signal liver issues that need attention.

Also, if you’re scheduled for surgery or any procedure, let the medical team know you’re on ledipasvir, as it may affect anesthesia or recovery plans.

Bottom Line

Ledipasvir is a key part of modern hepatitis C therapy. When taken as directed, it offers a high cure rate with few side effects. Keeping to the dosing schedule, watching for drug interactions, and staying in touch with your doctor are the best ways to make the treatment work for you.